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OPSUMIT IMPROVES FUNCTIONAL AND HAEMODYNAMIC PARAMETERS WHEN USED IN EARLY COMBINATION THERAPY1

Initial double combination therapy with OPSUMIT and tadalafil led to significant improvements from baseline to Week 16 in cardiopulmonary haemodynamics, functional parameters, NT-proBNP and risk profile in newly diagnosed, treatment-naive patients with PAH.1

SECONDARY ENDPOINTS: HAEMODYNAMIC PARAMETERS1

Initial double combination therapy with OPSUMIT and tadalafil improved multiple haemodynamic parameters from baseline to Week 16, including:1

*N=46; at Week 16 missing data were imputed: 2 patients for PVR, 2 patients for WHO FC, 3 patients for 6MWD.1 PVR, pulmonary vascular resistance. CI, Confidence Interval. mRAP, mean right atrial pressure. mPAP, mean pulmonary arterial pressure. SvO2, mixed venous oxygen saturation. NT-proBNP, N-terminal pro-B-type natriuretic peptide. PAH, pulmonary arterial hypertension. PVR, pulmonary vascular resistance. 6MWD, 6-minute walk distance. WHO, World Health Organization. FC,functional class.

References: 

[1] Sibton O, Cottin V, Canuet M, et al. initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension. Eur Respir J. 2020 Sep 3;56 (3):2000673.

CP-263142

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